Recent published research shows that grapefruit and grapefruit juice can react adversely with over 40 prescription medications. Reaction to the combination can be toxic to the kidneys, cause GI bleeding, respiratory failure and even sudden death for people with comprised immune systems.
Wait, grapefruit is supposed to be heart healthy and help you to lose weight – right??? Well, yes, but it can also be a NEGATIVE thing, especially if you take mental health medication. Grapefruit can interact with certain antidepressants, potentially increasing their levels in the body and leading to adverse effects.
Mechanism of Interaction
Grapefruit contains furanocoumarins, which inhibit enzymes in the liver and intestines that metabolize certain drugs. When antidepressants are taken with grapefruit, their metabolism is slowed down, resulting in higher blood concentrations of the medication.
Antidepressants Affected
Several antidepressants can interact with grapefruit, including:
- Sertraline (Zoloft)
- Citalopram (Celexa)
- Escitalopram (Lexapro)
- Fluoxetine (Prozac)
- Paroxetine (Paxil)
- Amitriptyline (Elavil).
Potential Adverse Effects
Increased levels of antidepressants in the body can lead to:
- Side effects such as nausea, vomiting, diarrhea, and dizziness
- Increased risk of seizures
- Irregular heartbeat
- Low blood pressure
Recommendations:
If you are taking an antidepressant, it is important to avoid consuming grapefruit or grapefruit juice. This includes fresh grapefruit, grapefruit juice, and products that contain grapefruit flavoring. Do not discount cosmetics or any other toiletries such as shampoos and body washes.
Talk to your doctor about any potential interactions between grapefruit and your medications. They may recommend avoiding grapefruit or adjusting your dosage accordingly.
Other Citrus Fruits:
Some other citrus fruits, such as Seville oranges and tangelos, may also contain furanocoumarins and interact with medications. It is best to avoid these fruits as well if you are taking antidepressants.
